NEUROMUSCULAR CRISIS: MYASTHENIA GRAVIS
Hello my
intellectual readers hope all are doing fine. Thanks for giving your few
minutes, Today I am here with the new topic Myasthenia Gravis!
Myasthenia
gravis is basically a kind of neuromuscular disorder. It is categorized as the
autoimmune disease. Autoimmune disease occurs when our immune system does not identify our host cells and
take them as antigen. Body immune system tries to kill or damage its own body
cells and tissue and consequently affect the organ and body.
In
the case of Myasthenia gravis antibody produced invade neuromuscular junction
affect the release of Acetylcholine which is the major neurotransmitter of the
cholinergic system of our Autonomic nervous system and responsible for the
proper communication between nerve and muscle. It can be defined as
interference of communication between nerves and muscles.
It
leads to beginning voluntary muscle weakness and fatigue that varies in severity from person to
person. It is a slow progressive disease that may affect the whole body
and leads to different symptoms affecting as follows:
Eye: drooping
of one or both eye lids double vision (diplopia)
Face and
throat Altered
voice and speaking, difficulty in swallowing chewing and limited facial
expressions
Pain
in neck and limb muscles, difficulty in walking, using your arms and hand even
holding head up.
Myasthenic
crisis refers
to condition when even muscles associated to breathing get affected. Person is
not able to breath by its own. Emergency treatment involve mechanical
assistance, medication and blood filtering techniques.
As
in the case of all autoimmune disease treatment is always an invincible
challenge. It can be controlled with drugs of class Anti Cholinesterase (Choline-esterase
inhibitor), corticosteroids and immune-suppressants orally
intravenous therapy include plasmapharesis and IV immunoglobulin therapy.
Deepti
M Sati
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